Our Work
The UhlhaasLab is situated at the Department of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy, Charité-Universitätsmedizin Berlin. We conduct research into the psychological and biological factors underlying mental disorders, such as psychosis, with the goal to identify novel diagnostic approaches and support the development of more effective treatments. We are particularly interested in emerging mental disorders in young people, i.e. between 12-25 year of age.
In the lab, we use Electro/Magnetoencephalography (EEG/MEG) with a particular focus on the role of neural oscillations in psychosis and related disorders. Moreover, we also use functional and anatomical Magnetic Resonance Imaging (fMRI/MRI) as well as Magnetic Resonance Spectroscopy (MRS). More recently, we begun to explore the potential of brain stimulation approaches, such as transcranial direct/alternating current stimulation (tDCS/tACS). We also have ongoing research to explore E-mental health approaches to detect and treat mental disorders in young people.
Research in the lab is currently supported by the German Research Foundation (DFG), the Einstein Foundation and Boehringer Ingelheim.
Representative publlications:
1) Brickwedde, M., Anders, P., Krüger, P., Sander, T., Uhlhaas. P.J. (2025). OPM quantum sensors enhance non-invasive neuroimaging performance. bioRxiv 2025.05.30.657044; doi: https://doi.org/10.1101/2025.05.30.657044
2) Rademacher J et al. (2025). Computational modeling of ketamine-induced changes in gamma-band oscillations: The contribution of parvalbumin and somatostatin interneurons. PLoS Comput Biol. 2025 Jun 9;21(6):e1013118.
3) Uhlhaas PJ et al. (2023). Towards a youth mental health paradigm: a perspective and roadmap. Mol Psychiatry. 28(8):3171-3181.
4) Grent-‘t-Jong et al. (2021). 40-Hz Auditory Steady-State Responses Characterize Circuit Dysfunctions and Predict Clinical Outcomes in Clinical-High-Risk Participants: A MEG Study. Biological Psychiatry 94(7):550-560.
5) Haining K et al. (2020). Neuropsychological deficits in participants at clinical high risk for psychosis recruited from the community: relationships to functioning and clinical symptoms. Psychol Med. 2020 Jan;50(1):77-85.